Dutasteride – instructions for use, price, analogues

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Dutasteride – instructions for use, price, analogues

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Violation of the hormonal balance in the male body, in particular – increasing the level of the hormone dihydrotestosetron, leads to the development of prostatic hyperplasia, the concomitant manifestation of which is the difficulty of outflow of urine in acute or latent form. To inhibit (prevent the production of) dihydrotestosterone synthetic substance of selective action is used – Dutasteride, which is part of preparations with various trade names.

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The active substance and its orientation
Dutasteride was developed and patented for the first time in the United States of America; it was produced in mass production in 2001 as part of a drug under the trade name Avodart, which is still used today. In 2015, the term of the patent for the substance ended and it began to be used in the production of generic drugs.

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The increase in the level of the hormone dihydrotestosterone in men leads to an uncontrolled proliferation of the prostate gland with the subsequent possible degeneration into a malignant form.

In addition, the elevated background of dihydrotestosterone in men is the cause of alopecia (hair loss on the head) and hirsorutism (body hair in women).

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Hyperplasia of the prostate gland is considered as a precancerous state of the body, requires special attention and corrective therapeutic and sometimes surgical interventions. One of the substances that selectively reduced the level of dihydrotestosterone was Dutasteride.

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The substance inhibits the activity of 5-alpha-reductase enzymes of the 1 st and 2 nd types, acting on the hormone testosterone, preventing it from turning into an excess amount of dihydrotestosterone.

The prostate gland, not getting supernormal hormone dihydrotestosterone, stops uncontrolled proliferation of its tissues and the process of hyperplasia stops. As a result of a decrease in the volume of the gland, the compression of the urinary tract ceases and urine output is facilitated, and, consequently, inflammatory stagnant phenomena also disappear.

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